A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

Brown, P J; Winegar, D A; Plunket, K D; Moore, L B; Lewis, M C; Wilson, J G; Sundseth, S S; Koble, C S; Wu, Z; Chapman, J M; Lehmann, J M; Kliewer, S A; Willson, T M

Brown, P J; Winegar, D A; Plunket, K D; Moore, L B; Lewis, M C; Wilson, J G; Sundseth, S S; Koble, C S; Wu, Z; Chapman, J M; Lehmann, J M; Kliewer, S A; Willson, T M.

Affiliation

Brown PJ; Department of Medicinal Chemistry, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709, USA. pjb5890@glaxowellcome.com

J Med Chem ; 42(19): 3785-8, 1999 Sep 23.

Article in En | MEDLINE | ID: mdl-10508427

Subject(s)

Butyrates/pharmacology; DNA-Binding Proteins/agonists; Hypolipidemic Agents/pharmacology; Lipid Metabolism; Nuclear Proteins/agonists; Phenylurea Compounds/pharmacology; Receptors, Cytoplasmic and Nuclear/agonists; Transcription Factors/agonists; Zinc Fingers; Animals; Fenofibrate/pharmacology; Humans; Male; Mice; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Transcription Factors / Butyrates / Nuclear Proteins / Zinc Fingers / Receptors, Cytoplasmic and Nuclear / DNA-Binding Proteins / Lipid Metabolism / Hypolipidemic Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1999 Document type: Article Affiliation country: United States

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