Detection of specific immunoglobulin E during maternal, fetal, and congenital toxoplasmosis.
J Clin Microbiol
; 37(11): 3487-90, 1999 Nov.
Article
in En
| MEDLINE
| ID: mdl-10523539
ABSTRACT
Toxoplasma immunoglobulin E (IgE) antibodies in 664 serum samples were evaluated by using an immunocapture method with a suspension of tachyzoites prepared in the laboratory in order to evaluate its usefulness in the diagnosis of acute Toxoplasma gondii infection during pregnancy, congenital infection, and progressive toxoplasmosis. IgE antibodies were never detected in sera from seronegative women, from patients with chronic toxoplasma infection, or from infants without congenital toxoplasmosis. In contrast, they were detected in 86.6% of patients with toxoplasmic seroconversion, and compared with IgA and IgM, the short kinetics of IgE was useful to date the infection precisely. For the diagnosis of congenital toxoplasmosis, specific IgE detected was less frequently than IgM or IgA (25 versus 67.3%), but its detection during follow-up of children may be interesting, reflecting an immunological rebound. Finally, IgE was detected early and persisted longer in progressive toxoplasmosis with cervical adenopathies, so it was also a good marker of the evolution of toxoplasma infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin E
/
Antibodies, Protozoan
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Toxoplasmosis
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Pregnancy Complications, Parasitic
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
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Child
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Child, preschool
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Female
/
Humans
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Infant
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Middle aged
/
Newborn
/
Pregnancy
Language:
En
Journal:
J Clin Microbiol
Year:
1999
Document type:
Article
Affiliation country:
France