Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.

Campiani, G; Morelli, E; Fabbrini, M; Nacci, V; Greco, G; Novellino, E; Ramunno, A; Maga, G; Spadari, S; Caliendo, G; Bergamini, A; Faggioli, E; Uccella, I; Bolacchi, F; Marini, S; Coletta, M; Nacca, A; Caccia, S

Campiani, G; Morelli, E; Fabbrini, M; Nacci, V; Greco, G; Novellino, E; Ramunno, A; Maga, G; Spadari, S; Caliendo, G; Bergamini, A; Faggioli, E; Uccella, I; Bolacchi, F; Marini, S; Coletta, M; Nacca, A; Caccia, S.

Affiliation

Campiani G; Dipartimento di Scienze Farmaceutiche, Facolta' di Farmacia, Universita' degli Studi di Salerno, via Ponte don Melillo, 84084 Fisciano (SA), Italy. campiani@unisa.it

J Med Chem ; 42(21): 4462-70, 1999 Oct 21.

Article in En | MEDLINE | ID: mdl-10543890

Subject(s)

Anti-HIV Agents/chemical synthesis; Azepines/chemical synthesis; HIV Reverse Transcriptase/antagonists & inhibitors; HIV-1/drug effects; Reverse Transcriptase Inhibitors/chemical synthesis; Animals; Anti-HIV Agents/chemistry; Anti-HIV Agents/pharmacology; Anti-HIV Agents/toxicity; Azepines/chemistry; Azepines/pharmacology; Azepines/toxicity; Cell Line; Drug Design; Drug Synergism; Fluorescent Antibody Technique; Humans; Mice; Models, Molecular; Reverse Transcriptase Inhibitors/chemistry; Reverse Transcriptase Inhibitors/pharmacology; Reverse Transcriptase Inhibitors/toxicity; Structure-Activity Relationship; Zidovudine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Azepines / HIV-1 / Reverse Transcriptase Inhibitors / Anti-HIV Agents / HIV Reverse Transcriptase Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1999 Document type: Article Affiliation country: Italy

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