Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient L-amino acid-defined diet in rats.

Tsujiuchi, T; Tsutsumi, M; Sasaki, Y; Takahama, M; Konishi, Y

Tsujiuchi, T; Tsutsumi, M; Sasaki, Y; Takahama, M; Konishi, Y.

Affiliation

Tsujiuchi T; Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara.

Jpn J Cancer Res ; 90(9): 909-13, 1999 Sep.

Article in En | MEDLINE | ID: mdl-10551317

Subject(s)

Carcinoma, Hepatocellular/genetics; CpG Islands; Focal Nodular Hyperplasia/genetics; Gene Expression Regulation, Neoplastic; Liver Neoplasms/genetics; Proto-Oncogene Proteins c-myc/genetics; Amino Acids/adverse effects; Animals; Carcinoma, Hepatocellular/chemically induced; Choline/adverse effects; CpG Islands/genetics; DNA Methylation; Diet; Focal Nodular Hyperplasia/chemically induced; Food, Formulated/adverse effects; Liver Neoplasms/chemically induced; Male; Proto-Oncogene Proteins c-myc/biosynthesis; Rats; Rats, Inbred F344

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins c-myc / Carcinoma, Hepatocellular / CpG Islands / Focal Nodular Hyperplasia / Liver Neoplasms Limits: Animals Language: En Journal: Jpn J Cancer Res Journal subject: NEOPLASIAS Year: 1999 Document type: Article Country of publication: Japan

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