Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency.

Critchfield, J W; Ho, O; Roberts, B D; Van Lint, C; Verdin, E; Butera, S T

Critchfield, J W; Ho, O; Roberts, B D; Van Lint, C; Verdin, E; Butera, S T.

Affiliation

Critchfield JW; HIV and Retrovirology Branch, Division of AIDS, STD and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

Antivir Chem Chemother ; 10(5): 275-84, 1999 Sep.

Article in En | MEDLINE | ID: mdl-10574182

Subject(s)

Anti-HIV Agents/pharmacology; HIV-1/drug effects; HL-60 Cells/virology; Isoquinolines/pharmacology; RNA, Viral/drug effects; Sulfonamides/pharmacology; Transcription, Genetic/drug effects; Virus Latency/genetics; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology; Chromatin/genetics; Chromatin/physiology; Enzyme Inhibitors/pharmacology; HIV Infections/drug therapy; HIV Infections/virology; HIV-1/genetics; HIV-1/growth & development; HIV-1/physiology; HL-60 Cells/metabolism; Humans; NF-kappa B/antagonists & inhibitors; NF-kappa B/physiology; Protein Kinase Inhibitors; RNA, Viral/genetics; Tumor Necrosis Factor-alpha/pharmacology; Virus Activation/drug effects; Virus Activation/genetics; Virus Latency/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Transcription, Genetic / RNA, Viral / HIV-1 / Virus Latency / HL-60 Cells / Anti-HIV Agents / Isoquinolines Type of study: Prognostic_studies Limits: Humans Language: En Journal: Antivir Chem Chemother Journal subject: QUIMICA / TERAPIA POR MEDICAMENTOS / VIROLOGIA Year: 1999 Document type: Article Affiliation country: United States Country of publication: United kingdom

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