Responses to potential vasoactive substances of isolated mammary blood vessels from lactating sows.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
; 124(1): 57-64, 1999 Sep.
Article
in En
| MEDLINE
| ID: mdl-10579649
ABSTRACT
The purpose of the investigation was to examine the response of the milk vein and the mammary artery to potential vasoactive substances in lactating sows. The response on artery and vein segments from the same sow was measured for the following substances noradrenaline (NA), serotonin (5-HT), prostaglandin F2alpha (PGF2alpha), prostacyclin (PGI2), histamine (Hi) and potassium (K+). Interestingly, the contractile force in the mammary vein segments expressed per weight unit (mN/mg) was 1.5-2.5 fold larger than in the artery segments when NA, 5-HT and PGF2alpha were used, but similar for K+, Hi and PGI2. In vein segments, the order of sensitivity to the substances expressed by their pD2 values was 5-HT > NA = PGF2alpha > Hi > K+. The present findings suggest that NA, 5-HT, PGF2alpha, PGI2, and Hi are involved in mammary blood flow regulation in the sow, and the mammary venous system may be as important as the mammary arterial system in this regulation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Swine
/
Vasoconstriction
/
Veins
/
Mammary Glands, Animal
/
Mammary Arteries
Limits:
Animals
Language:
En
Journal:
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
Journal subject:
ENDOCRINOLOGIA
/
FARMACOLOGIA
/
TOXICOLOGIA
Year:
1999
Document type:
Article