Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria. Production, isolation, physico-chemical and biological properties.

Sasse, F; Böhlendorf, B; Herrmann, M; Kunze, B; Forche, E; Steinmetz, H; Höfle, G; Reichenbach, H; Hermann, M

Sasse, F; Böhlendorf, B; Herrmann, M; Kunze, B; Forche, E; Steinmetz, H; Höfle, G; Reichenbach, H; Hermann, M.

Affiliation

Sasse F; GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Braunschweig, Germany.

J Antibiot (Tokyo) ; 52(8): 721-9, 1999 Aug.

Article in En | MEDLINE | ID: mdl-10580385

Subject(s)

Acrylates/isolation & purification; Acrylates/pharmacology; Antifungal Agents/isolation & purification; Antifungal Agents/pharmacology; Cell Respiration/drug effects; Myxococcales/metabolism; Thiazoles/isolation & purification; Thiazoles/pharmacology; Acrylates/chemistry; Acrylates/metabolism; Animals; Antifungal Agents/chemistry; Antifungal Agents/metabolism; Cytochrome b Group/drug effects; Cytochrome b Group/metabolism; Drug Evaluation, Preclinical; Energy Metabolism/drug effects; Fatty Acids, Unsaturated/chemistry; Fatty Acids, Unsaturated/pharmacology; Fermentation; Humans; Infant; Inhibitory Concentration 50; Methacrylates; Mice; Microbial Sensitivity Tests; Mitochondria, Heart/drug effects; Mitochondria, Heart/metabolism; Myxococcales/chemistry; NAD/metabolism; Strobilurins; Structure-Activity Relationship; Thiazoles/chemistry; Thiazoles/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Acrylates / Myxococcales / Cell Respiration / Antifungal Agents Limits: Animals / Humans / Infant Language: En Journal: J Antibiot (Tokyo) Year: 1999 Document type: Article Affiliation country: Germany

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