Microglial proliferation in cortical neural cultures exposed to feline immunodeficiency virus.
J Neuroimmunol
; 101(1): 15-26, 1999 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-10580809
ABSTRACT
Microglia are thought to play an important role in neurodegenerative changes due to infection with human or animal immunodeficiency viruses. Using feline immunodeficiency virus and cat neural cultures, we observed a dramatic increase in the accumulation of microglia from a basal rate of 5-7% day(-1) to 25-126% day(-1). Both live virus and heat-inactivated virus induced proliferation. Negligible proliferation was seen in purified microglial cultures. Conditioned medium from astrocytes or mixed neural cultures treated with feline immunodeficiency virus stimulated the proliferation of purified microglia. Disease progression may be facilitated by early non-infectious interactions of lentiviruses with neural tissue that promote the activation and proliferation of microglia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Microglia
/
Immunodeficiency Virus, Feline
Type of study:
Etiology_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
J Neuroimmunol
Year:
1999
Document type:
Article
Affiliation country:
United States