Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation.
Oncogene
; 18(50): 7115-23, 1999 Nov 25.
Article
in En
| MEDLINE
| ID: mdl-10597313
ABSTRACT
Oncogenic variants of the cellular Ras protein are often associated with different types of human cancers. However, the mechanisms by which oncogenic Ras induces transformation are not fully established. Expression of the transcriptional repressor Par-4 was down-regulated by oncogenic Ras via the Raf-MEK-ERK pathway. Restoration of Par-4 levels by abrogation of the Raf-MEK-ERK pathway with the MEK-inhibitor PD98059 or by ectopic Par-4, that acted to inhibit ERK expression and activation, was sufficient to suppress oncogenic Ras-induced transformation. These findings identify Par-4 as a novel target that has to be down-modulated by oncogenic Ras for successful transformation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carrier Proteins
/
Down-Regulation
/
Cell Transformation, Neoplastic
/
Proto-Oncogene Proteins p21(ras)
/
Intracellular Signaling Peptides and Proteins
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Oncogene
Journal subject:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Year:
1999
Document type:
Article
Affiliation country:
United States