Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

Huang, X; Cuajungco, M P; Atwood, C S; Hartshorn, M A; Tyndall, J D; Hanson, G R; Stokes, K C; Leopold, M; Multhaup, G; Goldstein, L E; Scarpa, R C; Saunders, A J; Lim, J; Moir, R D; Glabe, C; Bowden, E F; Masters, C L; Fairlie, D P; Tanzi, R E; Bush, A I

Huang, X; Cuajungco, M P; Atwood, C S; Hartshorn, M A; Tyndall, J D; Hanson, G R; Stokes, K C; Leopold, M; Multhaup, G; Goldstein, L E; Scarpa, R C; Saunders, A J; Lim, J; Moir, R D; Glabe, C; Bowden, E F; Masters, C L; Fairlie, D P; Tanzi, R E; Bush, A I.

Affiliation

Huang X; Laboratory for Oxidation Biology, Genetics and Aging Unit, and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

J Biol Chem ; 274(52): 37111-6, 1999 Dec 24.

Article in En | MEDLINE | ID: mdl-10601271

Subject(s)

Amyloid beta-Peptides/toxicity; Brain/drug effects; Copper/pharmacology; Hydrogen Peroxide/metabolism; Animals; Cells, Cultured; Computer Simulation; Copper/metabolism; Electron Spin Resonance Spectroscopy; Oxidation-Reduction; Rats

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Amyloid beta-Peptides / Copper / Hydrogen Peroxide Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 1999 Document type: Article Affiliation country: United States Country of publication: United States

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