Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1.

Schubart, D B; Rolink, A; Schubart, K; Matthias, P

Schubart, D B; Rolink, A; Schubart, K; Matthias, P.

Affiliation

Schubart DB; Friedrich Miescher-Institute, Basel, Switzerland.

J Immunol ; 164(1): 18-22, 2000 Jan 01.

Article in En | MEDLINE | ID: mdl-10604987

Subject(s)

Agammaglobulinemia/genetics; B-Lymphocytes/immunology; Lymphopenia/genetics; Protein-Tyrosine Kinases/deficiency; Trans-Activators/deficiency; Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia/enzymology; Agammaglobulinemia/immunology; Agammaglobulinemia/pathology; Animals; B-Lymphocytes/enzymology; B-Lymphocytes/pathology; Cell Differentiation/genetics; Cell Differentiation/immunology; Female; Gene Expression Regulation/immunology; Gene Expression Regulation, Developmental/immunology; Genes, Immunoglobulin; Genetic Linkage/immunology; Humans; Immunoglobulins/biosynthesis; Immunoglobulins/blood; Lymphoid Tissue/pathology; Lymphopenia/enzymology; Lymphopenia/immunology; Lymphopenia/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Multigene Family/immunology; Phenotype; Protein-Tyrosine Kinases/genetics; Trans-Activators/genetics; X Chromosome/genetics; X Chromosome/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / B-Lymphocytes / Trans-Activators / Agammaglobulinemia / Lymphopenia Language: En Journal: J Immunol Year: 2000 Document type: Article Affiliation country: Switzerland Country of publication: United States

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