ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.

Lohmann, A B; Welch, S P

Lohmann, A B; Welch, S P.

Affiliation

Lohmann AB; Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 980613, Richmond, VA 23298-0613, USA.

Eur J Pharmacol ; 385(2-3): 119-27, 1999 Dec 03.

Article in En | MEDLINE | ID: mdl-10607867

Subject(s)

Adenosine Triphosphate/physiology; Analgesics/pharmacology; Potassium Channels/drug effects; Receptors, Opioid/physiology; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer/pharmacology; Animals; Cromakalim/pharmacology; Diazoxide/pharmacology; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-/pharmacology; Enkephalin, Leucine/analogs & derivatives; Enkephalin, Leucine/pharmacology; Glyburide/pharmacology; Injections, Intraventricular; Ion Channel Gating/physiology; Male; Mice; Mice, Inbred ICR; Morphine/pharmacology; Naltrexone/analogs & derivatives; Naltrexone/pharmacology; Narcotic Antagonists; Nociceptors/drug effects; Opioid Peptides/drug effects; Opioid Peptides/metabolism; Pain/prevention & control; Potassium Channels/physiology; Receptors, Opioid/agonists; Receptors, Opioid, delta/agonists; Receptors, Opioid, delta/antagonists & inhibitors; Receptors, Opioid, kappa/antagonists & inhibitors; Receptors, Opioid, mu/antagonists & inhibitors; Somatostatin/analogs & derivatives; Somatostatin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Potassium Channels / Adenosine Triphosphate / Receptors, Opioid / Analgesics Language: En Journal: Eur J Pharmacol Year: 1999 Document type: Article Affiliation country: United States Country of publication: Netherlands

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