Mouse forebrain development. The role of Emx2 homeobox gene.
C R Acad Sci III
; 322(10): 837-42, 1999 Oct.
Article
in En
| MEDLINE
| ID: mdl-10609088
ABSTRACT
Over the last few years great progress has been made in the understanding of the formation of the mouse forebrain. Among the genes involved in this process, the mouse Emx homeobox genes Emx1 and particularly Emx2 play a primary role. Here we describe the mRNA and protein expression related to Emx2 in the developing mouse telencephalon, as well as the results obtained studying the corresponding knock-out mice. Our findings indicate a role for this gene in the specification of the forebrain via the control of cell proliferation, as well as in guiding neuronal migration during development through the cortical plate. These studies will hopefully enable us to better understand the molecular mechanisms underlying the formation of the mouse cerebral cortex as well as to establish relevant interactions between the various proteins present in this region of the brain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression
/
Genes, Homeobox
/
Prosencephalon
/
Homeodomain Proteins
/
Nerve Tissue Proteins
Limits:
Animals
Language:
En
Journal:
C R Acad Sci III
Journal subject:
BIOLOGIA
Year:
1999
Document type:
Article
Affiliation country:
Italy