p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.

Schürmann, A; Mooney, A F; Sanders, L C; Sells, M A; Wang, H G; Reed, J C; Bokoch, G M

Schürmann, A; Mooney, A F; Sanders, L C; Sells, M A; Wang, H G; Reed, J C; Bokoch, G M.

Affiliation

Schürmann A; Institut für Pharmakologie und Toxikologie, Medizinische Fakulät, Rheinisch-Westfälische Technische Hochschule Aachen, D52057 Aachen, Germany.

Mol Cell Biol ; 20(2): 453-61, 2000 Jan.

Article in En | MEDLINE | ID: mdl-10611223

Subject(s)

Apoptosis; Carrier Proteins/metabolism; Protein Serine-Threonine Kinases/metabolism; Tyrosine 3-Monooxygenase; 14-3-3 Proteins; Animals; Apoptosis/drug effects; Carrier Proteins/antagonists & inhibitors; Carrier Proteins/genetics; Cell Line; Cell Survival/drug effects; Enzyme Activation/drug effects; Interleukin-3/pharmacology; Mice; Mutation/genetics; Peptide Fragments/chemistry; Peptide Fragments/genetics; Peptide Fragments/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine/metabolism; Protein Binding; Protein Serine-Threonine Kinases/chemistry; Protein Serine-Threonine Kinases/genetics; Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Signal Transduction/drug effects; Sphingosine/analogs & derivatives; Sphingosine/pharmacology; bcl-Associated Death Protein; bcl-X Protein; cdc42 GTP-Binding Protein/metabolism; p21-Activated Kinases; rho GTP-Binding Proteins/antagonists & inhibitors; rho GTP-Binding Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine 3-Monooxygenase / Carrier Proteins / Protein Serine-Threonine Kinases / Apoptosis Language: En Journal: Mol Cell Biol Year: 2000 Document type: Article Affiliation country: Germany Country of publication: United States

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