Intracellular signalling pathways of okadaic acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors: okadaic acid regulates Shc phosphorylation by mechanisms independent of insulin.

Sawa, T; Sasaoka, T; Hirai, H; Ishihara, H; Ishiki, M; Wada, T; Kobayashi, M

Sawa, T; Sasaoka, T; Hirai, H; Ishihara, H; Ishiki, M; Wada, T; Kobayashi, M.

Affiliation

Sawa T; First Department of Medicine, Toyama Medical & Pharmaceutical University, Sugitani, Japan.

Cell Signal ; 11(11): 797-803, 1999 Nov.

Article in En | MEDLINE | ID: mdl-10617282

Subject(s)

Adaptor Proteins, Signal Transducing; Insulin/metabolism; MAP Kinase Signaling System; Okadaic Acid/metabolism; Receptor, Insulin/metabolism; src Homology Domains; Animals; Cell Line; DNA/biosynthesis; Enzyme Inhibitors/metabolism; Enzyme Inhibitors/pharmacology; Fibroblasts/cytology; Fibroblasts/drug effects; GRB2 Adaptor Protein; Intracellular Fluid/metabolism; Kinetics; Mitogen-Activated Protein Kinases/metabolism; Mitogens/pharmacology; Okadaic Acid/pharmacology; Phosphorylation; Proteins/metabolism; Rats; Time Factors; Tyrosine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Insulin / Src Homology Domains / Okadaic Acid / MAP Kinase Signaling System / Adaptor Proteins, Signal Transducing / Insulin Limits: Animals Language: En Journal: Cell Signal Year: 1999 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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