Glucocorticoids inhibit calcium- and calcineurin-dependent activation of the human IL-4 promoter.

Chen, R; Burke, T F; Cumberland, J E; Brummet, M; Beck, L A; Casolaro, V; Georas, S N

Chen, R; Burke, T F; Cumberland, J E; Brummet, M; Beck, L A; Casolaro, V; Georas, S N.

Affiliation

Chen R; Division of Pulmonary Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.

J Immunol ; 164(2): 825-32, 2000 Jan 15.

Article in En | MEDLINE | ID: mdl-10623828

Subject(s)

Calcineurin/physiology; Calcium/physiology; Dexamethasone/pharmacology; Immunosuppressive Agents/pharmacology; Interleukin-4/genetics; Lymphocyte Activation/drug effects; Nuclear Proteins; Promoter Regions, Genetic/immunology; Base Composition; Calcineurin/metabolism; Calcineurin Inhibitors; Calcium/antagonists & inhibitors; Cell Nucleus/drug effects; Cell Nucleus/metabolism; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Enzyme Activation/genetics; Enzyme Activation/immunology; Humans; Interleukin-4/metabolism; Jurkat Cells; NFATC Transcription Factors; Promoter Regions, Genetic/drug effects; Protein Kinase C/antagonists & inhibitors; Protein Kinase C/physiology; Response Elements/drug effects; Response Elements/immunology; Transcription Factors/antagonists & inhibitors; Transcription Factors/biosynthesis; Transcription Factors/genetics; Transcription Factors/metabolism; Transfection

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Dexamethasone / Nuclear Proteins / Lymphocyte Activation / Calcium / Interleukin-4 / Promoter Regions, Genetic / Calcineurin / Immunosuppressive Agents Limits: Humans Language: En Journal: J Immunol Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links