[Outpatient chemotherapy with infusional 5-fluorouracil in advanced gastrointestinal cancer].
Gan To Kagaku Ryoho
; 26 Suppl 2: 346-50, 1999 Dec.
Article
in Ja
| MEDLINE
| ID: mdl-10630245
ABSTRACT
These studies were designed to evaluate the efficacy, toxicity, and resulting quality of life (QOL) of outpatient chemotherapy with infusional 5-FU for advanced gastrointestinal cancer. Schedule, sch. A Treatment consisted of CI 5-FU 200 mg/m2/day, days 1-28, IVB Leucovorin 20 mg/m2 q week. Fifteen patients with advanced gastrointestinal cancer were treated to maintain the efficacy of prior inpatient chemotherapy. Twenty-one patients treated with adjuvant chemotherapy were added to evaluate toxicity and QOL. The mean time to progression (TTP) was 2.6 months. Grade 2 toxicities were seen, including mucositis (23%) and diarrhea (7%). Hand-foot syndrome was seen 60% of patients. The mean QOL score was 89.5 +/- 7.8. Sch.B Treatment consisted of weekly 24 h infusion of 5-FU 2,600 mg/m2. 5-FU was administered using a Groshong catheter and Baxter infusor LV5 (5 ml/hr). Nine patients with advanced gastrointestinal cancer were treated. Twenty-one patients were treated with adjuvant chemotherapy. The mean TTP was 3.6 month. Grade 2 toxicities were seen, including leucocytopenia (7%), mucositis (3%), diarrhea (10%), and nausea and vomiting (10%). The mean QOL score was 82.6 +/- 10.7. In conclusion, both 5-FU schedules are feasible for outpatient chemotherapy for advanced gastrointestinal cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Infusion Pumps
/
Antineoplastic Combined Chemotherapy Protocols
/
Home Infusion Therapy
/
Ambulatory Care
/
Gastrointestinal Neoplasms
Aspects:
Patient_preference
Limits:
Humans
/
Male
/
Middle aged
Language:
Ja
Journal:
Gan To Kagaku Ryoho
Year:
1999
Document type:
Article
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP