Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein (CREB) and compensatory overexpression of the activator CREMtau in the human adrenocortical cancer cell line H295R.

Groussin, L; Massias, J F; Bertagna, X; Bertherat, J

Groussin, L; Massias, J F; Bertagna, X; Bertherat, J.

Affiliation

Groussin L; Groupe d'Etude en Physiopathologie Endocrinienne, Centre National de la Recherche Scientifique, UPR1524, Institut Cochin de Génétique Moléculaire, Université René Descartes-Paris V, France.

J Clin Endocrinol Metab ; 85(1): 345-54, 2000 Jan.

Article in En | MEDLINE | ID: mdl-10634409

Subject(s)

Adrenal Cortex Neoplasms/genetics; Adrenal Cortex Neoplasms/metabolism; Cyclic AMP Response Element-Binding Protein/biosynthesis; DNA-Binding Proteins/biosynthesis; Gene Expression Regulation, Neoplastic/genetics; Repressor Proteins/biosynthesis; Activating Transcription Factor 1; Activating Transcription Factor 2; Blotting, Western; Cell Line; Cloning, Molecular; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein/genetics; DNA-Binding Proteins/genetics; Electrophoresis; Humans; RNA, Neoplasm/biosynthesis; RNA, Neoplasm/genetics; Repressor Proteins/genetics; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors/biosynthesis; Transcription Factors/genetics; Up-Regulation/drug effects; Up-Regulation/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Gene Expression Regulation, Neoplastic / Cyclic AMP Response Element-Binding Protein / Adrenal Cortex Neoplasms / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Clin Endocrinol Metab Year: 2000 Document type: Article Affiliation country: France Country of publication: United States

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