Chromosomes, Human, Pair 12/genetics; Chromosomes, Human, Pair 21/genetics; DNA-Binding Proteins; Leukemia, Myeloid/genetics; Neoplasm Proteins/genetics; Oncogene Proteins, Fusion/genetics; Proto-Oncogene Proteins; Receptors, Granulocyte Colony-Stimulating Factor/deficiency; Transcription Factors/genetics; Translocation, Genetic; Acute Disease; Apoptosis/drug effects; Blotting, Western; Cell Differentiation; Cell Division; Cell Lineage; Chromosomes, Human, Pair 12/ultrastructure; Chromosomes, Human, Pair 21/ultrastructure; Core Binding Factor Alpha 2 Subunit; DNA, Complementary/genetics; Flow Cytometry; Gene Expression Regulation, Leukemic; Granulocyte Colony-Stimulating Factor/pharmacology; Humans; Leukemia, Myeloid/pathology; Neoplasm Proteins/analysis; Neoplasm Proteins/chemistry; Peroxidase/analysis; Protein Structure, Tertiary; RUNX1 Translocation Partner 1 Protein; Receptors, Granulocyte Colony-Stimulating Factor/genetics; Sequence Deletion; Transcription, Genetic