Clonal propagation of primate offspring by embryo splitting.
Science
; 287(5451): 317-9, 2000 Jan 14.
Article
in En
| MEDLINE
| ID: mdl-10634789
ABSTRACT
Primates that are identical in both nuclear and cytoplasmic components have not been produced by current cloning strategies, yet such identicals represent the ideal model for investigations of human diseases. Here, genetically identical nonhuman embryos were produced as twin and larger sets by separation and reaggregation of blastomeres of cleavage-stage embryos. A total of 368 multiples were created by the splitting of 107 rhesus embryos with four pregnancies established after 13 embryo transfers (31% versus 53% in vitro fertilization controls). The birth of Tetra, a healthy female cloned from a quarter of an embryo, proves that this approach can result in live offspring.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blastomeres
/
Cleavage Stage, Ovum
/
Cloning, Organism
/
Embryonic and Fetal Development
/
Macaca mulatta
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Science
Year:
2000
Document type:
Article
Affiliation country:
United States
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA