Immunisation against varicella in end stage and pre-end stage renal failure. Trans-Pennine Paediatric Nephrology Study Group.
Arch Dis Child
; 82(2): 141-3, 2000 Feb.
Article
in En
| MEDLINE
| ID: mdl-10648369
ABSTRACT
OBJECTIVES:
To investigate the seroconversion rate and duration of persistence of protective antibody titres after varicella immunisation in children with renal failure.DESIGN:
32 children (25 end stage and 7 pre-end stage renal failure) were immunised using 2 x 2,000 plaque forming unit doses of varicella vaccine 3 months apart. Varicella antibody titres were measured by enzyme linked immunosorbent assay.RESULTS:
All children initially seroconverted after immunisation. At a mean follow up of 20.3 months, 23 of 28 had protective antibody titres, 4 children having died of unrelated causes. Two children required a third booster dose. 11 children underwent renal transplantation; 10 had protective titres at the time of transplantation and, at a mean of 23.4 months after immunisation, 6 currently have protective titres. Minor side effects occurred after 11 vaccine doses in 9 children. No child developed varicella, despite 10 clear episodes of exposure to the wild-type virus.CONCLUSIONS:
Varicella immunisation in children with end stage and pre-end stage renal failure results in a high rate of seroconversion and persistence of protective antibody titres. More widespread use of the vaccine before renal transplantation is recommended.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Herpesvirus 3, Human
/
Chickenpox Vaccine
/
Kidney Failure, Chronic
/
Antibodies, Viral
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
Arch Dis Child
Year:
2000
Document type:
Article
Affiliation country:
United kingdom