Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides.

Knappik, A; Ge, L; Honegger, A; Pack, P; Fischer, M; Wellnhofer, G; Hoess, A; Wölle, J; Plückthun, A; Virnekäs, B

Knappik, A; Ge, L; Honegger, A; Pack, P; Fischer, M; Wellnhofer, G; Hoess, A; Wölle, J; Plückthun, A; Virnekäs, B.

Affiliation

Knappik A; MorphoSys AG, Lena-Christ-Str. 48, Martinsried/Munich, 82152, Germany. knappik@morphosys.de

J Mol Biol ; 296(1): 57-86, 2000 Feb 11.

Article in En | MEDLINE | ID: mdl-10656818

Subject(s)

Consensus Sequence/genetics; Immunoglobulin Variable Region/biosynthesis; Immunoglobulin Variable Region/genetics; Mutagenesis, Insertional/genetics; Oligodeoxyribonucleotides/genetics; Peptide Library; Amino Acid Sequence; Antibody Affinity; Antibody Diversity; Cloning, Molecular; Combinatorial Chemistry Techniques; Escherichia coli/genetics; Escherichia coli/growth & development; Genes, Immunoglobulin/genetics; Humans; Immunoglobulin Variable Region/chemistry; Immunoglobulin Variable Region/immunology; Kinetics; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Random Allocation; Reproducibility of Results; Sequence Alignment; Solubility; Thermodynamics

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Collection: 01-internacional Database: MEDLINE Main subject: Oligodeoxyribonucleotides / Immunoglobulin Variable Region / Consensus Sequence / Mutagenesis, Insertional / Peptide Library Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: J Mol Biol Year: 2000 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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