Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia.

Bellomo, D; Headrick, J P; Silins, G U; Paterson, C A; Thomas, P S; Gartside, M; Mould, A; Cahill, M M; Tonks, I D; Grimmond, S M; Townson, S; Wells, C; Little, M; Cummings, M C; Hayward, N K; Kay, G F

Bellomo, D; Headrick, J P; Silins, G U; Paterson, C A; Thomas, P S; Gartside, M; Mould, A; Cahill, M M; Tonks, I D; Grimmond, S M; Townson, S; Wells, C; Little, M; Cummings, M C; Hayward, N K; Kay, G F.

Affiliation

Bellomo D; QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research, Australia.

Circ Res ; 86(2): E29-35, 2000 Feb 04.

Article in En | MEDLINE | ID: mdl-10666423

Subject(s)

Coronary Vessel Anomalies/genetics; Endothelial Growth Factors/physiology; Heart Defects, Congenital/genetics; Heart/growth & development; Myocardial Ischemia/genetics; Aging; Animals; Animals, Newborn; Coronary Vessel Anomalies/metabolism; Coronary Vessels/metabolism; Endothelial Growth Factors/genetics; Endothelial Growth Factors/metabolism; Female; Heart/physiology; Heart Defects, Congenital/physiopathology; Immunohistochemistry; Male; Mice; Mice, Knockout; Myocardial Ischemia/physiopathology; Myocardium/metabolism; Vascular Endothelial Growth Factor B

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelial Growth Factors / Myocardial Ischemia / Coronary Vessel Anomalies / Heart / Heart Defects, Congenital Limits: Animals Language: En Journal: Circ Res Year: 2000 Document type: Article Affiliation country: Australia

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