Chronic mitochondrial inhibition induces selective motoneuron death in vitro: a new model for amyotrophic lateral sclerosis.

Kaal, E C; Vlug, A S; Versleijen, M W; Kuilman, M; Joosten, E A; Bär, P R

Kaal, E C; Vlug, A S; Versleijen, M W; Kuilman, M; Joosten, E A; Bär, P R.

Affiliation

Kaal EC; Laboratory for Experimental Neurology, University Medical Center Utrecht, The Netherlands.

J Neurochem ; 74(3): 1158-65, 2000 Mar.

Article in En | MEDLINE | ID: mdl-10693948

Subject(s)

Mitochondria/physiology; Motor Neurons/physiology; Adenosine Triphosphate/metabolism; Amyotrophic Lateral Sclerosis/etiology; Animals; Cell Survival/drug effects; Cell Survival/physiology; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors/poisoning; In Vitro Techniques; Malonates/poisoning; Mitochondria/drug effects; Motor Neurons/drug effects; Neurons/drug effects; Neurons/physiology; Neuroprotective Agents/pharmacology; Rats; Sodium Azide/pharmacology; Spinal Cord/cytology; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Mitochondria / Motor Neurons Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2000 Document type: Article Affiliation country: Netherlands

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