[Improvement of the maintenance therapy after methylprednisolone pulse therapy--effect of prednisolone combined with immunosuppressants].
Ryumachi
; 39(6): 829-35, 1999 Dec.
Article
in Ja
| MEDLINE
| ID: mdl-10695406
ABSTRACT
OBJECTIVES:
We investigated the effect of the combination therapy of prednisolone (PSL) and immunosuppressants after methylprednisolone pulse therapy.METHODS:
A protocol of PSL (15-20 mg/day) and mizoribine (150-200 mg/day) after methylprednisolone (mPSL) pulses was used for 2 years to treat 7 patients (PSL + MZB group). Cyclophosphamide (CYC) pulse therapy was added to the combined therapy in 4 patients with severe lupus nephritis. The total dose of predinisolone, and side effects were compared with those in 6 patients who were treated with PSL (30 mg/kg) alone after mPSL pulse therapy (PSL group).RESULTS:
No relapses occurred in the PSL + MZB group, although all of 6 patients relapsed in the PSL Group. The total doses of PSL in the PSL + MZB group was about 70% of the PSL Group. There were two patients with Herpes-Zoster infection and one patient with liver dysfunction as side effects, with no differences in the frequency of side effects between the was groups.CONCLUSIONS:
Combination maintenance therapy with prednisolone and immunosuppressants after methylprednisolone pulse therapy was effective in preventing relapse.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ribonucleosides
/
Lupus Nephritis
/
Methylprednisolone
/
Cyclophosphamide
/
Immunosuppressive Agents
/
Anti-Inflammatory Agents
Type of study:
Guideline
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Ja
Journal:
Ryumachi
Year:
1999
Document type:
Article
Publication country:
JAPAN
/
JAPON
/
JAPÃO
/
JP