Effect of glutathione-modulating compounds on platinum compounds-induced cytotoxicity in human glioma cell lines.

Iida, M; Doi, H; Asamoto, S; Sugiyama, H; Sakagami, H; Kuribayashi, N; Takeda, M; Okamura, Y; Matsumoto, K

Iida, M; Doi, H; Asamoto, S; Sugiyama, H; Sakagami, H; Kuribayashi, N; Takeda, M; Okamura, Y; Matsumoto, K.

Affiliation

Iida M; Department of Neurosurgery, Tokyo Metropolitan Ebara Hospital, Japan. masaiida-e@ebara-hp.ota.tokyo.jp

Anticancer Res ; 19(6B): 5383-4, 1999.

Article in En | MEDLINE | ID: mdl-10697565

ABSTRACT

ABSTRACT

The relation between the effect of glutathione(GSH)-modulating compounds and platinum compounds (Cisplatin, Nedaplatin)-induced cytotoxicity was investigated. Pretreatment of human glioblastoma (T98G, U87MG) and glioma (KG1C) cell lines with L-buthionine-[S,R]-sulfoximine, which decrease the intracellular GSH concentration, remarkably increased their sensitivity against platinum compounds, whereas pretreatment with N-acetyl-L-cysteine, which increase the intracellular GSH concentration, only marginally protected the cells from the cytotoxic effect of platinum compounds. The results suggest that platinum compounds-induced cytotoxicity can be modified by GSH-modulating compounds in glioblastoma and glioma cell lines.

Subject(s)

Acetylcysteine/pharmacology; Brain Neoplasms/pathology; Buthionine Sulfoximine/pharmacology; Cisplatin/pharmacology; Glioma/pathology; Glutathione/metabolism; Organoplatinum Compounds/pharmacology; Antineoplastic Agents/pharmacology; Drug Synergism; Humans; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Organoplatinum Compounds / Acetylcysteine / Brain Neoplasms / Cisplatin / Buthionine Sulfoximine / Glioma / Glutathione Limits: Humans Language: En Journal: Anticancer Res Year: 1999 Document type: Article Affiliation country: Japan

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