Immunohistochemical localization of modified C-reactive protein antigen in normal vascular tissue.
Am J Med Sci
; 319(2): 79-83, 2000 Feb.
Article
in En
| MEDLINE
| ID: mdl-10698090
ABSTRACT
BACKGROUND:
The prototypic acute phase reactant, C-reactive protein (CRP), is a serum soluble, cyclic pentameric protein, the concentration of which increases markedly within hours of any tissue-damaging, inflammatory event. However, upon dissociation of its pentameric quaternary structure, CRP subunits undergo a spontaneous and irreversible conformational change. The resulting molecule, termed modified CRP or mCRP, has reduced aqueous solubility and a propensity to aggregate into a matrix-like lattice structure.METHODS:
Using monoclonal antibodies, normal human tissues were immunohistochemically screened for the presence of CRP as well as mCRP antigens.RESULTS:
Significant levels of mCRP were detected in the walls of blood vessels associated with normal human tissues. These data indicate that mCRP is a naturally occurring form of CRP and that it is a tissue-based rather than serum-based molecule.SIGNIFICANCE:
This report describes the localization of a stable form of CRP, mCRP, in blood vessels associated with normal human tissues.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arteries
/
C-Reactive Protein
/
Endocardium
/
Lung
Limits:
Humans
Language:
En
Journal:
Am J Med Sci
Year:
2000
Document type:
Article
Affiliation country:
United States