Identification of oxidative degradates of the thrombin inhibitor, 3-(2-phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methyleneca rboxamidomethylpyridinyl)pyrazinone, using liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry.

Wu, Y; Chen, X; Gier, L; Almarsson, O; Ostovic, D; Loper, A E

Wu, Y; Chen, X; Gier, L; Almarsson, O; Ostovic, D; Loper, A E.

Affiliation

Wu Y; Pharmaceutical Research and Development, Merck Research Laboratories, West Point, PA 19486, USA. yunhui_wu@merck.com

J Pharm Biomed Anal ; 20(3): 471-85, 1999 Jul.

Article in En | MEDLINE | ID: mdl-10701963

Subject(s)

Aminopyridines/chemistry; Pyrazines/chemistry; Thrombin/antagonists & inhibitors; Amides/analysis; Amides/chemistry; Aminopyridines/analysis; Chromatography, High Pressure Liquid/methods; Diamide/analogs & derivatives; Diamide/analysis; Diamide/chemistry; Drug Contamination; Drug Stability; Hydrogen Peroxide/chemistry; Hydroxylation/drug effects; Mass Spectrometry/methods; Molecular Weight; Oxidation-Reduction; Pyrazines/analysis; Reproducibility of Results; Solutions; Spectrophotometry, Ultraviolet; Tablets

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Thrombin / Aminopyridines Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: J Pharm Biomed Anal Year: 1999 Document type: Article Affiliation country: United States Country of publication: United kingdom

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