Epidemiology of holoprosencephaly in Hawaii, 1986-97.
Paediatr Perinat Epidemiol
; 14(1): 61-3, 2000 Jan.
Article
in En
| MEDLINE
| ID: mdl-10703035
ABSTRACT
Holoprosencephaly is a birth defect affecting the medial structures of the brain and face. This investigation examined the epidemiology of holoprosencephaly in Hawaii between 1986 and 1997, using data obtained from a birth defects registry, and compared the results with those of other population-based studies. Twenty-five cases were identified, producing a prevalence of 1.09 per 10,000 livebirths. There were 17 (68.0%) livebirths, two (8.0%) fetal deaths and six (24.0%) elective terminations. Ten (58.8%) of the livebirths died before the age of 1 year. Seven (28.0%) had a known chromosomal abnormality, most often trisomy 13. Prevalence rates were higher for maternal age > 39 years, maternal race/ethnicity of Far East Asian or Filipino, females and residence in Maui County. The small number of cases limited the statistical significance of the study. However, this report confirms many of the findings from the previous studies and adds new findings, particularly the higher prevalence among Far East Asians and Filipinos.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Holoprosencephaly
Type of study:
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Newborn
Country/Region as subject:
America do norte
Language:
En
Journal:
Paediatr Perinat Epidemiol
Journal subject:
EPIDEMIOLOGIA
/
PEDIATRIA
/
PERINATOLOGIA
Year:
2000
Document type:
Article
Affiliation country:
United States