Fusion of beta 2-adrenergic receptor to G alpha s in mammalian cells: identification of a specific signal transduction species not characteristic of constitutive activation or precoupling.

Small, K M; Forbes, S L; Rahman, F F; Liggett, S B

Small, K M; Forbes, S L; Rahman, F F; Liggett, S B.

Affiliation

Small KM; Departments of Medicine and Pharmacology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0564, USA.

Biochemistry ; 39(10): 2815-21, 2000 Mar 14.

Article in En | MEDLINE | ID: mdl-10704234

Subject(s)

Artificial Gene Fusion/methods; GTP-Binding Protein alpha Subunits, Gs/genetics; Receptors, Adrenergic, beta-2/genetics; Recombinant Fusion Proteins/chemical synthesis; Signal Transduction/genetics; Adenylyl Cyclases/genetics; Adenylyl Cyclases/metabolism; Animals; Blotting, Western; Cell Line; Cloning, Molecular; Cricetinae; Cricetulus; Enzyme Activation/genetics; GTP-Binding Protein alpha Subunits, Gs/biosynthesis; GTP-Binding Protein alpha Subunits, Gs/metabolism; Genetic Vectors/chemical synthesis; Genetic Vectors/metabolism; Ligands; Mutagenesis, Site-Directed; Precipitin Tests; Receptors, Adrenergic, beta-2/biosynthesis; Receptors, Adrenergic, beta-2/metabolism; Recombinant Fusion Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Signal Transduction / Receptors, Adrenergic, beta-2 / GTP-Binding Protein alpha Subunits, Gs / Artificial Gene Fusion Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Biochemistry Year: 2000 Document type: Article Affiliation country: United States

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