Enzyme self-inactivation is a main limitation of the preparation of eicosanoids. Enzymatic synthesis of thromboxane and 12(S)-hydroxytetraenoic acid.

Shram, S I; Myasoyedov, N F; Varfolomeyev, S D

Shram, S I; Myasoyedov, N F; Varfolomeyev, S D.

Affiliation

Shram SI; Department of Chemistry of Physiologically Active Agents, Institute of Molecular Genetics of RAS, Moscow, Russia.

Appl Biochem Biotechnol ; 82(1): 37-56, 1999 Oct.

Article in En | MEDLINE | ID: mdl-10707806

Subject(s)

Eicosanoids/biosynthesis; Prostaglandin-Endoperoxide Synthases/drug effects; Thromboxane-A Synthase/antagonists & inhibitors; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid/biosynthesis; Blood Platelets/drug effects; Blood Platelets/enzymology; Blood Platelets/metabolism; Cyclooxygenase Inhibitors/pharmacology; Humans; Microsomes/metabolism; Thromboxanes/biosynthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Thromboxane-A Synthase / Eicosanoids / Prostaglandin-Endoperoxide Synthases Limits: Humans Language: En Journal: Appl Biochem Biotechnol Year: 1999 Document type: Article Affiliation country: RUSSIA Country of publication: United States

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