Effects of radiotherapy for nasopharyngeal carcinoma on the paranasal sinuses: study based on computed tomography scanning.
J Otolaryngol
; 29(1): 23-7, 2000 Feb.
Article
in En
| MEDLINE
| ID: mdl-10709168
ABSTRACT
OBJECTIVE:
The purpose of this study was to determine if radiotherapy for nasopharyngeal carcinoma causes mucosal disease of the paranasal sinuses.DESIGN:
This study was a retrospective study.SETTING:
This study was conducted at a tertiary care centre.METHOD:
A series of 69 newly diagnosed patients, without pre-existing sinus disease, who were treated with high-dose radiotherapy participated. MAIN OUTCOMEMEASURES:
The prevalence, severity, and time course of mucosal abnormalities were analyzed, as judged by consecutive computed tomographies (CTs).RESULTS:
The CT study revealed that 58.8% of the postirradiation scans had mucosal disease of the sinuses. The maxillary sinus had the highest prevalence (42.3%) without statistical significance (p = .10). The difference by McNemar test for two follow-up scans was not significant (p = .48) and by Kappa test was significant (p = .04). The relationship between the prevalence and the time course post radiotherapy revealed that it remained a high prevalence until after the 4-year follow-up scans.CONCLUSIONS:
The results of this study confirm that chronic sinus disease is a common late complication of radiotherapy and it persists for years. Thus, aggressive treatment is indicated.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paranasal Sinuses
/
Carcinoma
/
Tomography, X-Ray Computed
/
Nasopharyngeal Neoplasms
Type of study:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Otolaryngol
Year:
2000
Document type:
Article
Affiliation country:
Taiwan