Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL.

Bodmer, J L; Meier, P; Tschopp, J; Schneider, P

Bodmer, J L; Meier, P; Tschopp, J; Schneider, P.

Affiliation

Bodmer JL; Institute of Biochemistry, University of Lausanne and Laboratoire Cantonal, CH-1066 Epalinges, Switzerland.

J Biol Chem ; 275(27): 20632-7, 2000 Jul 07.

Article in En | MEDLINE | ID: mdl-10748154

Subject(s)

Apoptosis; Cysteine/chemistry; Membrane Glycoproteins/chemistry; Tumor Necrosis Factor-alpha/chemistry; Amino Acid Sequence; Apoptosis Regulatory Proteins; Binding Sites; Disulfides/chemistry; Humans; Hydrogen-Ion Concentration; Membrane Glycoproteins/genetics; Membrane Glycoproteins/pharmacology; Molecular Sequence Data; Mutation; Protein Conformation; Receptors, Tumor Necrosis Factor/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Sequence Alignment; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/pharmacology; Zinc/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Tumor Necrosis Factor-alpha / Apoptosis / Cysteine Limits: Humans Language: En Journal: J Biol Chem Year: 2000 Document type: Article Affiliation country: Switzerland Country of publication: United States

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