IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice.

van Scott, M R; Justice, J P; Bradfield, J F; Enright, E; Sigounas, A; Sur, S

van Scott, M R; Justice, J P; Bradfield, J F; Enright, E; Sigounas, A; Sur, S.

Affiliation

van Scott MR; Department of Physiology, East Carolina University, Greenville, North Carolina 27858, USA. mrvanscott@brody.med.ecu.edu

Am J Physiol Lung Cell Mol Physiol ; 278(4): L667-74, 2000 Apr.

Article in En | MEDLINE | ID: mdl-10749743

Subject(s)

Bronchial Hyperreactivity/physiopathology; Cytokines/antagonists & inhibitors; Eosinophilia/pathology; Hypersensitivity/metabolism; Hypersensitivity/physiopathology; Interleukin-10/pharmacology; Th2 Cells/metabolism; Animals; Bronchitis/pathology; Bronchoalveolar Lavage Fluid/chemistry; Cytokines/biosynthesis; Cytokines/metabolism; Dose-Response Relationship, Drug; Female; Hypersensitivity/pathology; Interleukin-10/administration & dosage; Interleukin-10/analysis; Interleukin-10/blood; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pollen/immunology; Trachea

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Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Interleukin-10 / Bronchial Hyperreactivity / Th2 Cells / Eosinophilia / Hypersensitivity Limits: Animals Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2000 Document type: Article Affiliation country: United States Country of publication: United States

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