[Chance discovery of methanol poisoning during a state of inebriation]. / Découverte fortuite d'une intoxication au méthanol lors d'un état d'ébriété.
Ann Fr Anesth Reanim
; 19(3): 198-201, 2000 Mar.
Article
in Fr
| MEDLINE
| ID: mdl-10782245
ABSTRACT
We report a case of wood alcohol (methylated spirits) poisoning in a 40-year-old chronic alcoholic. The initial diagnosis of state of drunkenness was supported by the increased plasma level of ethanol (4.66 g.L-1) obtained with enzymatic method. The confirmation, using gas chromatography (GC), showed an unexpected peak with a retention time at 1.19 min, characteristic of methanol (0.41 g.L-1). The GC analysis of the absorbed beverage revealed a 5% methanol content. The osmolal gap was 115 mOsm.kg-1, with 13 mOsm.kg-1 due to methanol and 90 mOsm.kg-1 to ethanol. Seven hours after the ingestion, the anion gap was at 13 mmol-1. This result reflected the inhibition of methanol oxidation by alcohol-dehydrogenase, when the plasma ethanol concentration was above 1 g.L-1. This concentration was maintained by continuous intravenous administration of (Curéthyl-A) a 95% ethanol containing solution, until methanol concentration decreased below 0.2 g.L-1. The outcome was favourable without neurological and ophthalmological sequelae.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromatography, Gas
/
Methanol
/
Alcoholic Beverages
/
Alcoholic Intoxication
Type of study:
Diagnostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
Fr
Journal:
Ann Fr Anesth Reanim
Year:
2000
Document type:
Article
Affiliation country:
France