Bacterial Toxins/pharmacology; Chromaffin Cells/drug effects; Exocytosis/physiology; GTP-Binding Proteins/antagonists & inhibitors; 1-Phosphatidylinositol 4-Kinase/physiology; Actin Cytoskeleton/drug effects; Actin Cytoskeleton/ultrastructure; Actins/metabolism; Animals; Botulinum Toxins/pharmacology; Catecholamines/metabolism; Cell Membrane/physiology; Chromaffin Cells/cytology; Chromaffin Cells/metabolism; Clostridium/physiology; Cytoplasmic Granules/metabolism; Exocytosis/drug effects; GTP-Binding Proteins/classification; GTP-Binding Proteins/physiology; Humans; Intercellular Signaling Peptides and Proteins; Models, Biological; Peptides; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases/physiology; Signal Transduction/drug effects; Signal Transduction/physiology; Virulence Factors, Bordetella/pharmacology; Wasp Venoms/pharmacology; cdc42 GTP-Binding Protein/physiology; ras Proteins/antagonists & inhibitors; ras Proteins/physiology; rhoA GTP-Binding Protein/physiology