Beta-lactones as a new class of cysteine proteinase inhibitors: inhibition of hepatitis A virus 3C proteinase by N-Cbz-serine beta-lactone.

Lall, M S; Karvellas, C; Vederas, J C

Lall, M S; Karvellas, C; Vederas, J C.

Affiliation

Lall MS; Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.

Org Lett ; 1(5): 803-6, 1999 Sep 09.

Article in En | MEDLINE | ID: mdl-10823207

Subject(s)

Cysteine Proteinase Inhibitors/chemical synthesis; Lactones/chemistry; Serine/analogs & derivatives; Viral Proteins/antagonists & inhibitors; 3C Viral Proteases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors/pharmacology; Kinetics; Lactones/chemical synthesis; Lactones/pharmacology; Magnetic Resonance Spectroscopy; Serine/chemical synthesis; Serine/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Serine / Viral Proteins / Cysteine Proteinase Inhibitors / Lactones Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 1999 Document type: Article Country of publication: United States

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