Hypertriglyceridemic VLDL downregulates tissue plasminogen activator gene transcription through cis-repressive region(s) in the tissue plasminogen activator promoter in cultured human endothelial cells.

Tabengwa, E M; Benza, R L; Grenett, H E; Booyse, F M

Tabengwa, E M; Benza, R L; Grenett, H E; Booyse, F M.

Affiliation

Tabengwa EM; Division of Cardiovascular Disease, University of Alabama at Birmingham, USA. etabengwa@cardio.dom uab.edu

Arterioscler Thromb Vasc Biol ; 20(6): 1675-81, 2000 Jun.

Article in En | MEDLINE | ID: mdl-10845888

Subject(s)

Endothelium, Vascular/metabolism; Gene Expression Regulation/drug effects; Hypertriglyceridemia/blood; Lipoproteins, VLDL/pharmacology; Promoter Regions, Genetic; Tissue Plasminogen Activator/genetics; Cells, Cultured; Fibrinolysis/drug effects; Humans; Lipoproteins, VLDL/blood; RNA, Messenger/analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic/drug effects; Transfection; Umbilical Veins

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Hypertriglyceridemia / Gene Expression Regulation / Promoter Regions, Genetic / Tissue Plasminogen Activator / Lipoproteins, VLDL Limits: Humans Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2000 Document type: Article Country of publication: United States

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