CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells.
Blood
; 95(12): 3758-64, 2000 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-10845907
ABSTRACT
CD40 ligand (CD40L)/CD40 interactions play a central role in T-cell-dependent B-cell activation as previously shown by in vitro studies, the phenotype of CD40L knockout mice and the defective expression of CD40L in patients who have X-linked immunodeficiency with hyper-IgM. The distribution of CD40 in cells other than of myeloid and lymphoid lineages has suggested additional functions for this receptor/ligand couple. Here we show that CD40L stimulates myelopoiesis with a noticeable effect on megakaryocytopoiesis in cocultures of hematopoietic progenitor cells and bone marrow stromal cells. These results suggest a mechanism by which T-cell or platelet-associated or soluble CD40L may regulate myelopoiesis. (Blood. 2000;953758-3764)
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombopoietin
/
Hematopoietic Stem Cells
/
Endothelium, Vascular
/
Membrane Glycoproteins
/
Leukopoiesis
/
Membrane Proteins
Limits:
Animals
/
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Blood
Year:
2000
Document type:
Article
Affiliation country:
France