Inhibition by unsaturated fatty acids of type II secretory phospholipase A2 synthesis in guinea-pig alveolar macrophages evidence for the eicosanoid-independent pathway.

Alaoui El Azher, M; Havet, N; Singer, M; Dumarey, C; Touqui, L

Alaoui El Azher, M; Havet, N; Singer, M; Dumarey, C; Touqui, L.

Affiliation

Alaoui El Azher M; Unité de Pharmacologie Cellulaire, Unité Associée Pasteur/INSERM U485, Institut Pasteur, Paris, France.

Eur J Biochem ; 267(12): 3633-9, 2000 Jun.

Article in En | MEDLINE | ID: mdl-10848980

Subject(s)

Benzeneacetamides; Fatty Acids, Unsaturated/pharmacology; Macrophages, Alveolar/metabolism; Phospholipases A/antagonists & inhibitors; Phospholipases A/biosynthesis; Animals; Arachidonic Acid/metabolism; Arachidonic Acid/pharmacology; Aspirin/pharmacology; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System/metabolism; Fatty Acids, Unsaturated/metabolism; Group II Phospholipases A2; Guinea Pigs; Hydroxamic Acids/pharmacology; Inhibitory Concentration 50; Lipoxygenase/metabolism; Lipoxygenase Inhibitors/pharmacology; Macrophages, Alveolar/drug effects; Male; Phospholipases A/genetics; Phospholipases A2; Prostaglandin-Endoperoxide Synthases/metabolism; Triazoles/pharmacology; Tumor Necrosis Factor-alpha/biosynthesis; Tumor Necrosis Factor-alpha/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Phospholipases A / Macrophages, Alveolar / Benzeneacetamides / Fatty Acids, Unsaturated Limits: Animals Language: En Journal: Eur J Biochem Year: 2000 Document type: Article Affiliation country: France Country of publication: United kingdom

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