Phase II trial of docetaxel in Asian patients with inoperable stage III non-small cell lung cancer.
Acta Oncol
; 39(2): 225-9, 2000.
Article
in En
| MEDLINE
| ID: mdl-10859016
ABSTRACT
Docetaxel has a response rate of greater than 30% in first-line treatment of Western patients with advanced non-small cell lung cancer (NSCLC). The goal of this open-label. phase II study was to evaluate the activity and safety profile of docetaxel in Asian patients with inoperable untreated stage III NSCLC. Docetaxel was given at 100 mg/m2 as a 1-h infusion every 3 weeks. Prophylactic dexamethasone was given to reduce hypersensitivity reactions and edema. Thirty-five patients were enrolled in the study. The response rate was 34% (95% CI, 19%-50%) according to intent-to-treat analysis. No complete response was observed. Twenty-four patients (69%) had grade 3 or 4 neutropenia in cycle 1, and febrile neutropenia was seen in 12 patients. Six patients (17%) experienced mild fluid retention. Docetaxel is an active agent in first-line treatment of Asian patients with locally advanced NSCLC, with the main toxicity being neutropenia. Fluid retention was a minor problem in this study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paclitaxel
/
Carcinoma, Non-Small-Cell Lung
/
Taxoids
/
Lung Neoplasms
/
Antineoplastic Agents, Phytogenic
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Oncol
Journal subject:
NEOPLASIAS
Year:
2000
Document type:
Article
Affiliation country:
Singapore