Hepatocyte growth factor enhances MMP activity in human endothelial cells.
Biochem Biophys Res Commun
; 272(3): 900-5, 2000 Jun 16.
Article
in En
| MEDLINE
| ID: mdl-10860849
ABSTRACT
Scatter factor (SF) or hepatocyte growth factor (HGF) has been identified as an angiogenic factor. Angiogenesis requires not only tube formation but also invasion of pericytes and extracellular matrix (ECM) remodeling to promote new vessel stabilization. In the current study, the effect of SF/HGF on endothelial cell (EC) production of matrix metalloproteinases (MMPs) was explored. We showed that SF/HGF enhanced MT1-MMP synthesis and induced MMP-2 activation in two human EC lines dermal microvessel EC and coronary arterial EC. Furthermore, SF/HGF accelerated EC invasion into matrix, an activity that could be inhibited by a MMP inhibitor. We also demonstrated that the MAP kinase cascade is critical in signal transduction pathway from SF/HGF stimulation to MT1-MMP up-regulation. The current study indicates that MMP activation is a novel effect of SF/HGF on ECs.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endothelium, Vascular
/
Metalloendopeptidases
/
Hepatocyte Growth Factor
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2000
Document type:
Article
Affiliation country:
United States