DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.

Strissel, P L; Strick, R; Tomek, R J; Roe, B A; Rowley, J D; Zeleznik-Le, N J

Strissel, P L; Strick, R; Tomek, R J; Roe, B A; Rowley, J D; Zeleznik-Le, N J.

Affiliation

Strissel PL; University of Chicago Department of Medicine, Section of Hematology Oncology, Chicago, IL 60637-1470, USA. pstrisse@medicine.bsd.uchicago.edu

Hum Mol Genet ; 9(11): 1671-9, 2000 Jul 01.

Article in En | MEDLINE | ID: mdl-10861294

Subject(s)

DNA, Neoplasm/genetics; DNA-Binding Proteins/genetics; Leukemia/genetics; Nuclear Proteins/genetics; Oncogene Proteins, Fusion/genetics; Proto-Oncogenes; Transcription Factors; Binding Sites; Cell Line; Chromatin/genetics; DNA Topoisomerases, Type II/metabolism; DNA, Neoplasm/chemistry; Deoxyribonuclease I/metabolism; Histone-Lysine N-Methyltransferase; Humans; Introns; Jurkat Cells; K562 Cells; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins/metabolism; Recombination, Genetic; Sequence Analysis, DNA; Translocation, Genetic; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Proto-Oncogenes / DNA, Neoplasm / Nuclear Proteins / Leukemia / Oncogene Proteins, Fusion / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2000 Document type: Article Affiliation country: United States Country of publication: United kingdom

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