Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.

Li, D N; Seidel, A; Pritchard, M P; Wolf, C R; Friedberg, T

Li, D N; Seidel, A; Pritchard, M P; Wolf, C R; Friedberg, T.

Affiliation

Li DN; Biomedical Research Centre, University of Dundee Medical School, Ninewells Hospital, UK.

Pharmacogenetics ; 10(4): 343-53, 2000 Jun.

Article in En | MEDLINE | ID: mdl-10862525

Subject(s)

Aryl Hydrocarbon Hydroxylases; Carcinogens/metabolism; Cytochrome P-450 Enzyme System/genetics; Estradiol/analogs & derivatives; Estradiol/metabolism; Polymorphism, Genetic; Alleles; Base Sequence; Carcinogens/toxicity; Cytochrome P-450 CYP1B1; DNA Primers; DNA, Complementary; Dihydroxydihydrobenzopyrenes/pharmacokinetics; Estradiol/toxicity; Estrogens, Catechol; Ethanolamines/pharmacokinetics; Humans; Hydroxylation; Kinetics; Mutagenesis, Site-Directed; Oxazines/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Carcinogens / Aryl Hydrocarbon Hydroxylases / Cytochrome P-450 Enzyme System / Estradiol Limits: Humans Language: En Journal: Pharmacogenetics Year: 2000 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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