Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro.

Siwik, D A; Chang, D L; Colucci, W S

Siwik, D A; Chang, D L; Colucci, W S.

Affiliation

Siwik DA; Myocardial Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA. USA.

Circ Res ; 86(12): 1259-65, 2000 Jun 23.

Article in En | MEDLINE | ID: mdl-10864917

Subject(s)

Collagen/antagonists & inhibitors; Fibroblasts/metabolism; Interleukin-1/pharmacology; Matrix Metalloproteinases/metabolism; Myocardium/metabolism; Tumor Necrosis Factor-alpha/pharmacology; Animals; Cells, Cultured; Collagen/biosynthesis; Collagen/genetics; Inflammation Mediators/pharmacology; Matrix Metalloproteinases/genetics; Nitric Oxide/physiology; RNA, Messenger/antagonists & inhibitors; Rats

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Collagen / Interleukin-1 / Tumor Necrosis Factor-alpha / Matrix Metalloproteinases / Fibroblasts / Myocardium Limits: Animals Language: En Journal: Circ Res Year: 2000 Document type: Article Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links