Enzyme replacement therapy in mucopolysaccharidosis I: altered distribution and targeting of alpha-L-iduronidase in immunized rats.

Turner, C T; Hopwood, J J; Brooks, D A

Turner, C T; Hopwood, J J; Brooks, D A.

Affiliation

Turner CT; Department of Chemical Pathology, Women's and Children's Hospital, North Adelaide, South Australia, Australia.

Mol Genet Metab ; 69(4): 277-85, 2000 Apr.

Article in En | MEDLINE | ID: mdl-10870845

Subject(s)

Iduronidase/therapeutic use; Mucopolysaccharidosis I/drug therapy; Animals; Antibodies/blood; Antibodies/immunology; Biological Transport; Dose-Response Relationship, Drug; Drug Hypersensitivity/immunology; Humans; Iduronidase/immunology; Iduronidase/metabolism; Immunization; Injections, Subcutaneous; Liver/drug effects; Liver/enzymology; Mucopolysaccharidosis I/enzymology; Mucopolysaccharidosis I/immunology; Rats; Recombinant Proteins/immunology; Recombinant Proteins/metabolism; Recombinant Proteins/therapeutic use; Tissue Distribution; Tritium

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Collection: 01-internacional Database: MEDLINE Main subject: Mucopolysaccharidosis I / Iduronidase Limits: Animals / Humans Language: En Journal: Mol Genet Metab Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Year: 2000 Document type: Article Affiliation country: Australia Country of publication: United States

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