Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.

Batty, D; Rapic'-Otrin, V; Levine, A S; Wood, R D

Batty, D; Rapic'-Otrin, V; Levine, A S; Wood, R D.

Affiliation

Batty D; Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

J Mol Biol ; 300(2): 275-90, 2000 Jul 07.

Article in En | MEDLINE | ID: mdl-10873465

Subject(s)

DNA Damage/genetics; DNA Damage/radiation effects; DNA-Binding Proteins/metabolism; DNA/metabolism; DNA/radiation effects; Animals; Binding, Competitive; Cell Line; Cisplatin/pharmacology; DNA/genetics; DNA Damage/drug effects; DNA Repair/genetics; DNA Repair Enzymes; DNA, Single-Stranded/genetics; DNA, Single-Stranded/metabolism; Enzyme Activation; Humans; Kinetics; Macromolecular Substances; Protein Binding; Recombinant Proteins/metabolism; Substrate Specificity; Thermodynamics; Transcription, Genetic; Ultraviolet Rays

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Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / DNA / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Mol Biol Year: 2000 Document type: Article Affiliation country: United kingdom

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