ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor.
Nat Cell Biol
; 2(7): 407-14, 2000 Jul.
Article
in En
| MEDLINE
| ID: mdl-10878805
ABSTRACT
The ERBB receptors have a crucial role in morphogenesis and oncogenesis. We have identified a new PDZ protein we named ERBIN (ERBB2 interacting protein) that acts as an adaptor for the receptor ERBB2/HER2 in epithelia. ERBIN contains 16 leucine-rich repeats (LRRs) in its amino terminus and a PDZ (PSD-95/DLG/ZO-1) domain at its carboxy terminus, and belongs to a new PDZ protein family. The PDZ domain directly and specifically interacts with ERBB2/HER2. ERBIN and ERBB2/HER2 colocalize to the lateral membrane of human intestinal epithelial cells. The ERBIN-binding site in ERBB2/HER2 has a critical role in restricting this receptor to the basolateral membrane of epithelial cells, as mutation of the ERBIN-binding site leads to the mislocalization of the receptor in these cells. We suggest that ERBIN acts in the localization and signalling of ERBB2/HER2 in epithelia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carrier Proteins
/
Cell Polarity
/
Receptor, ErbB-2
/
Epithelial Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Cell Biol
Year:
2000
Document type:
Article
Affiliation country:
France