Chronic corticosterone impairs inhibitory avoidance in rats: possible link with atrophy of hippocampal CA3 neurons.
Pharmacol Biochem Behav
; 66(2): 235-40, 2000 Jun.
Article
in En
| MEDLINE
| ID: mdl-10880674
ABSTRACT
The aim of our work was to evaluate the effect of a chronic (22 days) administration of corticosterone, which induces supraphysiological serum levels of the hormone, on an inhibitory avoidance learning in rats (one-trial step-through learning task, footshock 0.5 mA, 2 s). We also studied hippocampal markers of neuroanatomical CA3 pyramidal neuron atrophy by using the Golgi staining method. Chronic exposure to high CORT serum levels induced a significant impairment of inhibitory avoidance learning. The CORT group also showed hippocampal glucocorticoid receptor (GR) downregulation and the decrease of hippocampal CA3 branch points and total dendritic length in the apical tree that would be causally related with the learning impairment.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Avoidance Learning
/
Corticosterone
/
Pyramidal Cells
Limits:
Animals
Language:
En
Journal:
Pharmacol Biochem Behav
Year:
2000
Document type:
Article
Affiliation country:
Argentina