Regression of a presumed meningioma with the antiestrogen agent mepitiostane. Case report.
J Neurosurg
; 93(1): 132-5, 2000 Jul.
Article
in En
| MEDLINE
| ID: mdl-10883917
ABSTRACT
This 68-year-old woman underwent a distal gastrectomy for gastric cancer in August 1994. A presumed meningioma of the falx was found incidentally on a staging examination of the gastric cancer, but the meningioma was not treated with surgery. Instead, after gastrectomy the patient received tegafur as adjuvant chemotherapy until February 1996, when she was readmitted to the hospital because of loss of appetite and emaciation but with no recurrence of the gastric cancer. A computerized tomography scan obtained during this second admission showed no change in the meningioma. To improve her general condition, tegafur was discontinued and she was started on a course of the antiestrogen agent mepitiostane. Administration of mepitiostane for approximately 2 years resulted in a marked regression (73%) of the meningioma. This is the first reported case of a presumed meningioma that regressed as a result of use of the antiestrogen agent mepitiostane.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Estrogen Antagonists
/
Androstanols
/
Meningeal Neoplasms
/
Meningioma
/
Antineoplastic Agents
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
J Neurosurg
Year:
2000
Document type:
Article
Affiliation country:
Japan
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA